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Why are generic pills cheaper than the brand name ones?

The principal reason for the reduced price of generic medicines is that the creation of the generic drug runs up less cost and therefore a lower price can be offered and still maintain profitability.
Manufacturers of generic drugs are mainly able to avoid the following three costs that brand name pharmaceutical companies incur: (1) costs associated with the research and development of the drug; (2) costs associated obtaining regulatory approval (i.e. proving safety and efficacy of a drug); and (3) marketing costs.
First, Generic manufacturers do not incur the cost of drug discovery and instead reverse-engineer existing brand name drugs to allow them to manufacture bioequivalent versions.
Second, generic manufacturers do not bear the burden of proving the safety and efficacy of the drugs through clinical trials - rather, generic manufacturers must prove the generic drug’s bioequivalancy to the existing drug.
Third, these companies receive the large benefit of the marketing and advertising that goes into pushing the innovator drug. The brand name drug has to prove itself in the eyes of the consumer, generic ones do not. The drugs that generic manufacturers are selling have been on the market for usually a decade or more and do not need additional advertising. For the same reason, generic manufacturers also do not give away sample doses to promote their products. The significant research, development and marketing costs incurred by the large pharmaceutical companies in introducing a new drug to the market is often cited as the reason for the high cost of new agents - they wish to recover these costs before the patent expires. Generic manufacturers do not incur these costs, with bioequivalence testing and manufacturing costing relatively little, and are able to charge significantly less than the brand.

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Diclofenac is used for:

Treating joint swelling, pain, and stiffness caused by osteoarthritis or rheumatoid arthritis in patients who are at a high risk of developing NSAID-induced ulcers or their complications. It may also be used for other conditions as determined by your doctor.

Diclofenac is an NSAID and prostaglandin analog combination. The prostaglandin maintains prostaglandin activity needed to protect the lining of the stomach and reduce acid secretion, reducing the risk of ulcers. The NSAID decreases prostaglandins that cause pain and inflammation, relieving joint pain.

It can also be used to reduce menstrual pain, dysmenorrhea.

Do NOT use Diclofenac if:

  • you are allergic to any ingredient in Diclofenac or other prostaglandins
  • you are pregnant
  • you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or an NSAID (eg, ibuprofen, naproxen, celecoxib)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diclofenac :

Some medical conditions may interact with Diclofenac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney or liver problems, the blood disease porphyria, bleeding problems, lupus, heart disease, ulcer problems, or high blood pressure
  • if you have asthma; bone marrow depression; canker sores; or a hole, bleeding, or destruction of tissue in the stomach or intestines; or you are dehydrated
  • if you drink alcohol

Some MEDICINES MAY INTERACT with Diclofenac. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, paroxetine) because the risk of side effects, such as bleeding, may be increased
  • Cyclosporine or methotrexate because the risk of toxicity may be increased
  • Lithium because the risk of its side effects may be increased by Diclofenac
  • Quinolone antibiotics (eg, ciprofloxacin) because the risk of side effects, such as seizures, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diclofenac :

Use Diclofenac as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Diclofenac comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Diclofenac refilled.
  • Take Diclofenac by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Do not take magnesium-containing antacids while taking Diclofenac. If an antacid is needed, use one with calcium or aluminum.
  • If you miss a dose of Diclofenac , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac.

Important safety information:

  • Diclofenac may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Diclofenac may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Diclofenac. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Diabetes patients - Diclofenac may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Women who are able to become pregnant should use effective birth control while they are taking Diclofenac. Talk with your doctor if you are unsure of effective birth control methods.
  • Lab tests, including complete blood cell counts, liver function tests, and electrolytes, may be performed while you use Diclofenac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Diclofenac should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Diclofenac if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Diclofenac is found in breast milk. Do not breast-feed while taking Diclofenac.

Possible side effects of Diclofenac :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; gas; headache; indigestion; nausea; stomach pain; swelling; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding and ulcers in the stomach and intestines; dark urine; fever; heart failure; increase in asthma attacks; increased liver injury; loss of appetite; severe diarrhea; sore throat; trouble breathing; unusual bleeding or bruising; vaginal bleeding after menopause; vision or hearing problems; vomit that looks like coffee grounds; weight loss; yellowing of the skin or eyes.

What is the shelf life of the pills?

  • The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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We have received both parts of the shipment, and my husband and I are very satisfied with the product.

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